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Answer: (A) Great-grandson
Explanation
Tracing the family relations generation by generation from top to bottom: A is the father of B (generation 1 down). B is the father of C, making C the grandchild of A (generation 2 down). C and his wife F have a son D, making D the child of C (generation 3 down).
Since D is a male relative located three generations below A, D is the great-grandson of A.